Benzimidazole derivatives aldehyde
Any sixmembered aromatic heterocycle.
SMARTS: [c;r6:1](-[NH1;$(N-[#6]):2]):[c;r6:3](-[NH2:4]).[#6:6]-[CH1;R0:5](=[OD1])>>[c:3]2:[c:1]:[n:2]:[c:5](-[#6:6]):[n:4]@2
Conditions
Reactant 1: phenyldiamine.
Reactant 2: aldehyde.
R1 = Ar, alkyl.
References
S. V. Ryabukhin, A. S. Plaskon, D. M. Volochnyuk, A. A. Tolmachev, Synthesis, 2006, 3715-3726.