Benzimidazole derivatives carboxylic-acid or ester
Any sixmembered aromatic heterocycle.
SMARTS: [c;r6:1](-[NH1;$(N-[#6]):2]):[c;r6:3](-[NH2:4]).[#6:6]-[C;R0:5](=[OD1])-[#8;H1,$(O-[CH3])]>>[c:3]2:[c:1]:[n:2]:[c:5](-[#6:6]):[n:4]@2
Conditions
Reactant 1: phenyldiamine.
Reactant 2: carboxylic acid or ester.
R1 = Ar, alkyl, vinyl, benzyl.
References
W. Cui, R. B. Kargbo, Z. Sajjadi-Hashemi, F. Ahmed, J. F. Gauuan, Synlett, 2012, 23, 247-250.