Tetrazole connect regioisomere 1
Not regioselective. Additional step: substitute halogen with azide.
SMARTS: [CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[*;#17,#35,#53]>>[C:1]1=[N:2]-N(-[C:3])-N=N-1
Conditions
Reactant 1: nitrile.
Reactant 2: alkyl halide.
R1, R2: alkyl. X: halogen.
References
J. Roh, T. V. Artamonova, K. Vávrová, G. I. Koldobskii, A. Hrabálek, Synthesis, 2009, 2175-217.
Other sources
Organic chemistry